Paul Turner, Senior Affiliate
An ongoing area of study concerns viral ecology, which addresses how viruses interact molecularly within their hosts, between their hosts, and with their environment. In specific, Turner and his laboratory members have used both phages and viruses of eukaryotes as laboratory models for elucidating evolutionary rules of RNA virus emergence. Paul Turner is the Elihu Professor of Ecology and Evolutionary Biology at Yale University, and school member in Microbiology at Yale School of Medicine. He research the evolutionary genetics of viruses, particularly bacteriophages that specifically infect bacterial pathogens, and RNA viruses which might be vector-transmitted by mosquitoes.
Professor Turner works with colleagues at VECTOR to review the natural history and evolution of pathogenic RNA viruses corresponding to Crimean Congo Hemorrhagic Fever. His non-research work focuses on improvement of human and laboratory capability for diagnostic microbiology in low-resource settings. Turner makes a compelling case that viruses are more biologically successful than cellular life, corresponding to in a 2013 evaluation that he coauthored . The article examines gauges of biological success, together with numerical abundance, environmental tolerance, type biodiversity, reproductive potential, and widespread influence on different organisms.
Evolutionary Constraints Of Viruses
Paul Turner describes the basic biology of viruses, and supplies an introduction to phage remedy, and how it may be improved by applying ‘evolution pondering. Dr. Paul Turner is Professor of Ecology and Evolutionary Biology at Yale University, and holds an appointment within the Microbiology Program at Yale School of Medicine. His laboratory research how viruses evolutionarily adapt to beat environmental challenges, similar to temperature adjustments or an infection of novel host species. Turner acquired his bachelor’s degree in Biology from the University of Rochester in 1988, and accomplished his graduate studies in microbial ecology and evolution at Michigan State University in 1995. Turner’s utilized research contains in search of natural products that could be helpful in combating necessary pathogens.
The primary focus of Paul Turner’s analysis is to check the evolutionary genetics and genomics of microbes, particularly the flexibility of viruses to adapt to modifications of their biotic and abiotic environments. These studies concern environmental challenges faced by viruses at all levels of biological group, including effects of adjustments in molecules, proteins, cells, populations, communities and ecosystems. His work is extremely interdisciplinary, employing microbiology, computational biology, genomics, molecular biology and mathematical-modeling approaches, and particularly experimental evolution (‘evolution-in-action’) research underneath managed laboratory conditions. Turner makes use of all kinds of RNA and DNA viruses in his research, including various lytic, temperate and filamentous phages that infect micro organism.
In one other examine his team demonstrated that a history of prior RNA virus evolution in multiple hosts can foster the emergence of those viruses in novel hosts . Infectious ailments are prevalent in Cambodia, a country that’s battling poor infrastructure. Streptococcus pneumoniae causes the most extreme type of pneumonia and is now focused by the pneumococcal conjugate vaccine. Additionally, Turner’s staff has demonstrated that viruses endure evolutionary commerce-offs across selective temperatures and throughout differing innate immune profiles of hosts.
- Paul Turner is the Elihu Professor of Ecology and Evolutionary Biology at Yale University, and college member in Microbiology at Yale School of Medicine.
- He also typically collaborates along with his graduate college students and postdoctoral fellows, crediting his college students and mentees for their inspiration and assist over time.
- With Lenski and a colleague, Turner used plasmids as models to check the theorized systematic commerce-off between infectious and intergenerational modes of parasite transmission .
- In 2016, he and his team isolated from a Connecticut pond a lytic phage, OMKO1, which attacks the frequent multidrug-resistant pathogen Pseudomonas aeruginosa .
- at Imperial College London, where his sponsors include John Warner, Stephen Durham and Gideon Lack.
Turner’s research incessantly makes use of microbes as mannequin methods to test evolutionary and ecological theories. With Lenski and a colleague, Turner used plasmids as models to test the theorized systematic trade-off between infectious and intergenerational modes of parasite transmission . The researchers confirmed that infectious parasites can not evolve to simultaneously maximize horizontal and vertical transfers between hosts.